Sarcoidosis
Fully developed
| Collection of epithelioid histiocytes throughout the dermis and sometimes throughout lobules of the subcutaneous fat; granulomas usually discrete, but my be confluent |
| Tiny focus of necrobiosis in the center of collections of histiocytes sometimes |
| Multinucleate histiocytes sometimes present within the granulomas |
| Inclusion, i.e., asteroid bodies(eosinophilic star shaped bodies) or Schaumann bodies (basophilic laminated concentric whorls) sometimes observed within some histiocytes, neither of the specific |
| Few or no lymphocytes at the periphery of collections of epithelioid histiocytes; granulomas at times, however, surrounded by numerous lymphocytes, especially in lobules in the subcutaneous fat |
Histopathological diffrential diagnosis